Voyager: Voyager Next-Generation CNS Capsids Featured at ASGCT 28th Annual Meeting

- Oral presentation on tau silencing gene therapy VY1706, which has previously shown up to 73% knockdown of tau mRNA in NHPs in the CNS following a single IV dose of 1.3e13 vg/kg -- Featured data also include anti-amyloid gene therapy for Alzheimer's disease, as well as multiple presentations on Voyager's continued enhancements to its highly BBB penetrant novel capsids - LEXINGTON, Mass., April 28, 2025 (GLOBE NEWSWIRE) -- Voyager Therapeutics, Inc. (NASDAQ:VYGR), a biotechnology company dedicated to leveraging genetics to treat neurological diseases, today announced eight oral and poster presentations at the upcoming American Society of Gene & Cell Therapy's (ASGCT) 28th annual meeting taking place in New Orleans, May 13-17, 2025."Voyager continues to raise the bar with our TRACER capsids. In multiple studies utilizing a variety of payloads, our capsids have transduced 43%-98% of neurons and 87-99% of astrocytes broadly across brain regions following a single intravenous 3e13 vg/kg dose in non-human primates," said Todd Carter, Ph.D., Chief Scientific Officer of Voyager Therapeutics. "Our new data at ASGCT build on our strong foundation in developing gene therapies for Alzheimer's disease: our tau silencing gene therapy VY1706, which will be featured in an oral presentation, has previously shown up to 73% knockdown of tau mRNA in NHPs following a single IV dose of 1.3e13 vg/kg, and we will also present data from our anti-amyloid gene therapy program. Our data also feature continued enhancements such as immune evasion to potentially increase the percentage of the population who could benefit from these treatments. With two INDs expected this year and another next year, we look forward to assessing and hopefully validating the performance of our capsids in humans."Anti-Tau and Anti-Amyloid Gene Therapies for Alzheimer's DiseaseOral Presentation: Intravenous delivery of VY1706, a CNS penetrant AAV gene therapy for Alzheimer's disease, provides broad tau lowering in NHP. Rajeev Sivasankaran, Ph.D., VP, Head of Neuroscience. Thursday, May 15, 2025, 8:50 a.m. - 9:15 a.m. CTCross-species BBB-penetrant IV-delivered AAV gene therapy provides broad and robust CNS tau lowering in tauopathy mouse models and non-human primate (#559). Hechen Bao, Ph.D., Scientist II, Neuroscience. Tuesday, May 13, 2025, 6:00 p.m. - 7:30 p.m. CTOne-time delivery of a vectorized anti-amyloid antibody for increased and sustained CNS expression and target engagement (#541). Cassandra Retzlaff, Ph.D., Scientist II, Neuroscience. Tuesday, May 13, 2025, 6:00 p.m. - 7:30 p.m. CTReducing Immunogenicity and Enhancing Developability and Manufacturing of CapsidsOral Presentation: Discovery of AAV9-derived CNS capsids evading pre-existing neutralizing antibodies. Damien Maura, Ph.D., Senior Scientist II, Capsid Discovery. Wednesday, ...Full story available on Benzinga.com