OpenOffice and PDFedit are two good tools for editing text in the pdf file. However, if you need to change the layout, add a picture etc, you need to find a new approach. Here's what I usually do: using ghostscript to generate TIFF files using this command gs -sDEVICE=tiff24nc -r150×150 -sPAPERSIZE=letter -sOutputFile=<output dir>/<base filename>%03d.tif -dNOPAUSE -dBATCH - <pdf [...]