A recent study published in the New England Journal of Medicine reported that in 2014 there were more than 2 million new HIV-1 infections worldwide, most of which occurred via sexual transmission. Effective HIV-1 prevention strategies are required to reduce the risk of viral transmission from infected persons to their sexual partners. Other studies involving serodiscordant couples have suggested that antiretroviral therapy (ART) in those with HIV-1 infection reduces the risk of sexual transmission.