IsoPlexis Blog Efficiently Generating and Selecting Broadly Neutralizing Antibodies with Mosaic Nanoparticle Immunization and Multiplexed Screening

Therapeutic monoclonal antibodies (mAbs) have become less effective against SARS-CoV-2 infections as new variants arise due to point mutations in the spike protein that reduce antibody binding. To induce production of broadly neutralizing antibodies that target a conserved receptor-binding domain (RBD) region, protecting against multiple SARS-CoV-2 variants and zoonotic sarbecoviruses, researchers at the California Institute [...]The post Efficiently Generating and Selecting Broadly Neutralizing Antibodies with Mosaic Nanoparticle Immunization and Multiplexed Screening appeared first on Bruker Cellular Analysis.