This morning I tried to open a PDF from GroupWise, our email program. Immediately, I got an error message in Adobe Acrobat Reader X, "There was an error opening this document. Access denied." Since we recently upgraded to Adobe Reader 10.0 (X), I figured it was a new security setting in the application.As it turns out, this new version of Acrobat is using the "principle of least privilege". I darn near bored myself to death reading a three-part series on Adobe's new Protected Mode.To make things simple for you, here are two ways for you fix the problem:A. Fix One PCLaunch Adobe Acrobat Reader XGo to: Edit > Preferences...Click on "General" in the left pane.Uncheck "Enable Protected Mode at startup"You will prompted with a dialog box to remind you to close the application for the change to go into effect. Click Yes.Click OK to save your change.Exit Adobe ReaderB. Fix Several PCs in Your OrganizationFollowing the above steps aren't practical if you have Adobe Acrobat installed on 1,000+ computers in 30 regional offices! Push this registry setting using your standard software deployment software.[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\10.0\Privileged]"bProtectedMode"=dword:00000000Microsoft Outlook and other email clientsI hear this will also fix the "There was an error opening this document. Access denied." error that is occurring with any email client, including Microsoft Outlook Express; Microsoft Outlook 2010, 2007, 2003; Eudora; Mozilla Thunderbird.Drop me a note below to let me know if this fixes your problem!